EARLY INTERVENTION IN ALZHEIMER’S DISEASE
Guiding patients from first signs and symptoms to intervention
Your patient’s initial cognitive complaint or observed impairment may be your trigger to screen, diagnose, and intervene. You can help your patients navigate this journey today.1-3
Diagnosis of MCI due to AD is an opportunity for meaningful interventions
Doctors have access to a range of evidence-based early interventions after diagnosis of MCI due to AD.3 Early diagnosis also provides the opportunity to prepare financial and end-of-life plans while cognitive impairment remains mild.3,4
The current pharmacological landscape for managing patients with Alzheimer’s disease includes symptomatic treatments, clinical trials, and treatments for comorbidities such as depression.5
Nonpharmacological interventions for your patients3,4,6
Early Interventions in AD Can Help Patients Along Their Journey
These interventions may be effective in3:
Nonpharmacological interventions may help change the direction of cognitive decline6
In the 2-year observational FINGER study, elderly patients showed 25 to 150% improvements in cognition due to non-pharmaceutical post-testing interventions.
- 25% change in overall cognition (as measured through a comprehensive neuropsychological test battery)
- 83% improvement in executive function
- 150% improvement in processing speed
Care partner interventions are an important component of overall care
As of 2017, 48% of care partners were unpaid while caring for a spouse, parent, or family member. Dementia care partners tend to provide more extensive assistance as the disease progresses, with an emphasis on self-care and mobility. The care required of family members can result in increased emotional stress and feelings of depression. Tailored interventions can have a positive impact on the well-being of care partners. Continued support for care partners is instrumental in treating Alzheimer’s disease holistically.4,5
- Cordell CB, Borson S, Boustani M, et al; and Medicare Detection of Cognitive Impairment Workgroup. Alzheimer’s Association recommendations for operationalizing the detection of cognitive impairment during the Medicare Annual Wellness Visit in a primary care setting. Alzheimers Dement. 2013;9(2):141-150.
- Michels TC, Tiu AY, Graver CJ. Neuropsychological evaluation in primary care. Am Fam Physician. 2010;82(5):495-502.
- Alzheimer’s Disease International. World Alzheimer Report 2011: the benefits of early diagnosis and intervention. https://www.alz.co.uk/research/world-report-2011. Accessed February 20, 2020.
- Alzheimer's Association. Alzheimer's Association Report: 2018 Alzheimer's disease facts and figures. Alzheimers Dement. 2018;14:367-429.
- Alzheimer's Association. Alzheimer's Association Report: 2020 Alzheimer's disease facts and figures. Alzheimers Dement. 2020;16(3):391-460.
- Ngandu T, Lehtisalo J, Solomon A, et al. A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial. Lancet. 2015;385(9984):2255-2263.